Related Experiment Video

Updated: Aug 8, 2026

Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma
06:15

Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma

Published on: October 27, 2014

Oncolytic adenoviral therapy for glioblastoma multiforme

Adam M Sonabend1, Ilya V Ulasov, Yu Han

  • 1Division of Neurosurgery, The University of Chicago, Illinois, USA.

Neurosurgical Focus
|May 20, 2006
PubMed

Insights

Oncolytic adenoviruses, engineered to replicate selectively in tumor cells, show promise for treating malignant glioma. Genetic modifications enhance their potential as effective neurooncology therapies.

Area of Science:

  • Oncology
  • Virology
  • Gene Therapy

Background:

  • Adenoviruses are historically significant vectors in human gene therapy, particularly for brain tumors.
  • Replication-defective adenoviral vectors have shown limited success in brain tumor trials.
  • This has driven the exploration of alternative therapeutic strategies.

Purpose of the Study:

  • To review genetic modification approaches for adenoviruses.
  • To discuss the application of these modified adenoviruses in neurooncology.
  • To highlight the potential of oncolytic adenoviruses for malignant glioma treatment.

Main Methods:

  • Discussing genetic modifications (transductional and transcriptional) to render adenoviruses conditionally replicative.
  • Reviewing the application of these modified adenoviruses in neurooncology.
  • Focusing on adenoviruses that selectively target and replicate within tumor cells.

Main Results:

  • Oncolytic adenoviruses demonstrate selective binding and replication in tumor cells.
  • Conditional replication enhances therapeutic potential for malignant glioma.
  • Genetic modifications are key to achieving oncolytic properties.

Conclusions:

  • Conditionally replicative adenoviruses offer significant promise for malignant glioma patients.
  • Genetic engineering of adenoviruses is crucial for developing effective neurooncology treatments.
  • Oncolytic adenoviruses represent a promising advancement in brain tumor gene therapy.

More Related Videos

Stereotactic Adoptive Transfer of Cytotoxic Immune Cells in Murine Models of Orthotopic Human Glioblastoma Multiforme Xenografts11:15

Stereotactic Adoptive Transfer of Cytotoxic Immune Cells in Murine Models of Orthotopic Human Glioblastoma Multiforme Xenografts

Published on: September 1, 2018

The Clinical Application of Tumor Treating Fields Therapy in Glioblastoma08:00

The Clinical Application of Tumor Treating Fields Therapy in Glioblastoma

Published on: April 16, 2019

Related Concept Videos

Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...