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Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach
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Synthesis of 1-formyldipyrromethanes

Marcin Ptaszek1, Brian E McDowell, Jonathan S Lindsey

  • 1Department of Chemistry, North Carolina State University, Raleigh, North Carolina 27695-8204, USA.

The Journal of Organic Chemistry
|May 20, 2006
PubMed
Summary

Two synthesis methods for 1-formyldipyrromethanes, crucial precursors for porphyrins and chlorins, were compared. The reaction involving mesitylmagnesium bromide followed by formylation proved more efficient for preparing these compounds.

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