Related Experiment Video
Updated: Aug 6, 2026

Examination of Mitotic and Meiotic Fission Yeast Nuclear Dynamics by Fluorescence Live-cell Microscopy
Published on: June 24, 2019
Nucleus-vacuole junctions in yeast: anatomy of a membrane contact site
1Department of Biology, University of Rochester, NY 14627, USA.
Abstract:
NV junctions (nucleus-vacuole junctions) in Saccharomyces cerevisiae are MCSs (membrane contact sites) formed through specific interactions between Vac8p on the vacuole membrane and Nvj1p in the outer nuclear membrane, which is continuous with the perinuclear ER (endoplasmic reticulum). NV junctions mediate a unique autophagic process that degrades portions of the yeast nucleus through a process called 'piecemeal microautophagy of the nucleus' (PMN). Our studies suggest that the lipid composition of NV junctions plays an important role in the biogenesis of PMN structures. NV junctions represent a unique model system for studying the biology of ER MCSs, as well as the molecular mechanism of selective microautophagy.
Related Concept Videos
Yeast Signaling
Contact-dependent Signaling
Gap Junctions
In animal cells, gap junctions are formed...
Gap Junctions
Overview of Cell-Cell Junctions
Occluding or Tight Junctions
Tight...
Gap Junctions
Overview of Cell-Cell Junctions
Occluding or Tight Junctions
Tight...

