Related Experiment Video

Updated: Aug 8, 2026

Left Atrial Stenosis Induced Pulmonary Venous Arterialization and Group 2 Pulmonary Hypertension in Rat
08:34

Left Atrial Stenosis Induced Pulmonary Venous Arterialization and Group 2 Pulmonary Hypertension in Rat

Published on: November 18, 2018

[Kawasaki disease: heart disease during childhood]

Ana M Schroh1, Pablo Domínguez, Lidia B Laghezza

  • 1Servicio de Cardiología Infantil, Hospital Pediátrico Dr. Humberto J. Notti, Mendoza, Argentina. schroh_md@hotmail.com

Revista Espanola De Cardiologia
|May 20, 2006
PubMed

Insights

Kawasaki disease can cause coronary artery abnormalities in children. Key risk factors for coronary aneurysms include young age, prolonged fever, elevated erythrocyte sedimentation, and pancarditis.

Area of Science:

  • Pediatric Cardiology
  • Immunology
  • Rheumatology

Context:

  • Kawasaki disease is a leading cause of acquired heart disease in children.
  • Coronary artery abnormalities are a significant concern, potentially leading to long-term cardiovascular complications.
  • Understanding risk factors and lesion types is crucial for effective management.

Purpose:

  • To identify risk factors associated with coronary lesions in Kawasaki disease.
  • To classify the types and severity of cardiac lesions observed.
  • To evaluate the long-term outcomes and mortality rates.

Summary:

  • This study analyzed 150 children diagnosed with Kawasaki disease.
  • 18% developed heart disease, with all cases showing coronary artery abnormalities.
  • Coronary aneurysms were the most common lesion, with diffuse ectasia and solitary aneurysms being frequent.
  • Pancarditis predicted giant coronary artery aneurysms. Risk factors included younger age (<27 months), prolonged fever (>8 days), elevated erythrocyte sedimentation rate (>70 mm), and pancarditis.
  • Mortality was 3.7%.

Impact:

  • Identifies critical risk factors for coronary aneurysm development in Kawasaki disease.
  • Provides detailed classification of coronary abnormalities, aiding in risk stratification.
  • Highlights the importance of early diagnosis and intervention to mitigate severe cardiac outcomes.

More Related Videos

Implantation of Total Artificial Heart in Congenital Heart Disease07:27

Implantation of Total Artificial Heart in Congenital Heart Disease

Published on: July 18, 2014

Related Concept Videos

Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
Rheumatic Heart Disease III: Medical Management01:21

Rheumatic Heart Disease III: Medical Management

Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
Rheumatic Heart Disease IV: Nursing Management01:20

Rheumatic Heart Disease IV: Nursing Management

AssessmentA comprehensive assessment is essential in managing a patient with rheumatic heart disease (RHD). Begin with obtaining a detailed medical history, including recent streptococcal infections, a history of rheumatic fever, or previously diagnosed rheumatic heart disease. Assess the patient for symptoms such as fever, chest pain, widespread joint pain (arthralgia), tachycardia, pericardial friction rub, muffled heart sounds, heart murmurs, peripheral edema, subcutaneous nodules, and...
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...