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Related Experiment Videos

NR3 protein expression in trigeminal neurons during postnatal development.

Kohji Ishihama1, Jack E Turman

  • 1First Department of Oral and Maxillofacial Surgery, Osaka University Graduate School of Dentistry, Osaka 565-0871, Japan.

Brain Research
|May 20, 2006
PubMed
Summary

The study reveals differential regulation of N-methyl-d-aspartate (NMDA) receptor subunits NR3A and NR3B in trigeminal neurons. This occurs during the developmental shift from suckling to chewing behaviors.

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Molecular Biology

Background:

  • N-methyl-d-aspartate (NMDA) receptors are crucial for oral motor activities.
  • Previous research established the role of NMDA receptors in these functions.

Purpose of the Study:

  • To investigate the developmental regulation of NR3A and NR3B NMDA receptor subunits.
  • To compare expression patterns in trigeminal motoneurons (Mo5) and mesencephalic trigeminal neurons (Me5).

Main Methods:

  • Immunohistochemical analysis of NR3A and NR3B protein expression.
  • Examination across different postnatal ages (P14, P21-23).

Main Results:

  • NR3A expression was present in both Mo5 and Me5, decreasing in Mo5 and caudal Me5 post-P14, but increasing in rostral Me5.

Related Experiment Videos

  • NR3B protein expression appeared in Mo5 only after P21-23.

    • Conclusions:

    • NR3A and NR3B expression is differentially regulated between Mo5 and Me5.
    • This differential regulation coincides with the developmental transition from suckling to chewing.