Outcome of pregnancy after first trimester exposure to H2 receptor antagonists

H2 antagonists are widely prescribed medications and are often consumed by women who are unaware of being pregnant. In 23 cases reported to the Motherisk program there were two spontaneous abortions, two therapeutic abortions, 18 normal births, and one infant with a large hemangioma of the upper right eyelid. The hemangioma was removed without incident. Our data suggest that cimetidine and ranitidine may not be teratogenic risk in humans.