[Coeliac disease an spastic paraplegia]

Area of Science:

• Neurology
• Immunology
• Gastroenterology

Background:

• Celiac disease (CD) is an immune-mediated disorder triggered by gluten in susceptible individuals.
• Neurological manifestations of CD are uncommon but can be severe, necessitating systematic evaluation.

Observation:

• Two unrelated patients from consanguineous marriages developed progressive spastic paraplegia.
• Paraplegia onset occurred 2 and 8 years after the initial diagnosis of celiac disease.

Findings:

• Radiological and biological findings were unremarkable, apart from those related to CD.
• The association between spastic paraplegia and celiac disease remains unclear.

Implications:

• Potential autoimmune, metabolic, or genetic mechanisms linking CD and spastic paraplegia warrant further investigation.
• The possibility of a coincidental occurrence of these conditions cannot be excluded.