Related Experiment Video
Updated: Aug 8, 2026

Formation of Dispersible Taohong Siwu Tablets
Published on: February 3, 2023
[Optimization of formulation of Fufang Danshen immediate release tablet by colligation score]
Rong-feng Hu1, Jia-bi Zhu, Dai-yin Peng
1Institute of Pharmaceutics, China Pharmaceutical University, Nanjing. rongfenghu2003@hotmail.com
Objective:
To optimize the formulation of immediate release tablet.
Method:
The immediate release tablet was prepared by using dry granules. The preparation was optimized by using orthogonal design which took the flow property of granules, the hardness, the disintegrating time and the dissolution rate of the tablet as indices.
Result:
The optimized formulation contained 40% microcrystalline cellulose, 10% sodium carboxymethyl starch and 15% dextrin. The hardness disintegrating time and T50 of the tablet were 4.5 kg, 3 min, 5 min respectively.
Conclusion:
It is successful to prepare on immediate release tablet using the optimized formula above.
Related Concept Videos
Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules
Factors Influencing Drug Absorption: Pharmaceutical Parameters
Factors Affecting Dissolution: Particle Size and Effective Surface Area
Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence
Drug Dissolution: Requirements and Profile Comparison
In Vitro Drug Dissolution: Compendial Testing Models I
