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Updated: Aug 8, 2026

Systematic Assessment of Mammalian Skull Specimens for Dental and Temporomandibular Joint Pathology
Published on: August 22, 2022
Longitudinal study of non-cavitated carious lesion progression in the primary dentition
John J Warren1, Steven M Levy, Barbara Broffitt
1Dental Science Bldg., The University of Iowa, Iowa City, IA 52242-1010, USA. john-warren@uiowa.edu
Objectives:
This study reports changes in non-cavitated tooth surface diagnoses after a 4-year period.
Methods:
Dental examinations were conducted for Iowa Fluoride Study cohort children who had non-cavitated lesions in the primary dentition and were also examined an average of 4 years later in the mixed dentition. Comparison of fluoride exposures, socioeconomic factors, and beverage consumption patterns were made between children who had lesions progress and those who did not.
Results:
Of 129 non-cavitated pit and fissure lesions in the first exams, 40 (31%) progressed to either frank decay or filled status, while among 132 noncavitated smooth surface lesions, 7 (5%) were filled and none had frank decay in the second exam. No fluoride, socioeconomic status or beverage variables were significantly associated with lesion progression.
Conclusions:
Non-cavitated smooth surface lesions rarely progressed in this age group, but nearly one-third of pit and fissure lesions progressed.
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