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Cyclization of alpha-synuclein derived peptide increases its chaperone-like activity

Thomas Doohun Kim1

  • 1Department Biological and Molecular Engineering, College of Engineering, Ajou University, Suwon, South Korea 443-749. doohunkim@ajou.ac.kr

Protein and Peptide Letters
|May 23, 2006
PubMed
Summary

Researchers explored C-terminal alpha-synuclein peptides for chaperone activity. A disulfide-crosslinked cyclic peptide demonstrated enhanced chaperone-like activity, preventing protein aggregation and activity loss.

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