Related Experiment Video
Updated: Aug 8, 2026

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals
Published on: December 16, 2022
Differences in null points between the left and right ventricles in contrast-enhanced inversion recovery MR imaging
1Department of Radiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan. yas-amano@nifty.com
Insights
Delayed contrast-enhanced MRI can detect right ventricular (RV) myocardial damage. Shorter inversion times may be needed for accurate RV null point assessment in cardiac MRI, especially in arrhythmogenic right ventricular cardiomyopathy.
Area of Science:
- Cardiovascular Magnetic Resonance Imaging
- Cardiac Electrophysiology
- Medical Imaging Techniques
Background:
- Delayed contrast-enhanced inversion recovery (IR) gradient-echo MRI is used for cardiac diseases.
- Previous studies suggest its utility in arrhythmogenic right ventricular cardiomyopathy (ARVC).
- Right ventricular (RV) myocardium null points on IR MRI are not well-established.
Purpose of the Study:
- To evaluate RV and left ventricular (LV) myocardial null points using IR fast multi-shot echo-planar imaging (Look-Locker sequence).
- To assess the significance of RV myocardial signal intensity in delayed contrast-enhanced MRI.
- To determine optimal imaging parameters for RV late enhancement detection.
Main Methods:
- Utilized IR fast multi-shot echo-planar imaging (Look-Locker sequence) in 26 cardiac patients.
- Assessed null points of RV and LV myocardium.
- Analyzed RV and LV myocardial signal intensities on delayed contrast-enhanced MR images.
Main Results:
- RV myocardial null points were shorter than LV null points in 9 out of 26 patients.
- Significantly higher RV myocardial signals were observed compared to LV signals.
- This indicates potential underestimation of RV myocardial late enhancement.
Conclusions:
- RV myocardial null points differ from LV, requiring specific attention during IR MRI.
- Delayed contrast-enhanced MRI may necessitate shorter inversion times for accurate RV assessment.
- Further research is needed to optimize RV myocardial imaging protocols.
Abstract:
Delayed contrast-enhanced inversion recovery (IR) gradient-echo MR imaging has been applied to several cardiac diseases, including myocarditis, sarcoidosis, hypertrophic cardiomyopathy, and myocardial damages induced by medical procedures. Although a preliminary study has indicated the usefulness of this imaging for the detection of right ventricular (RV) myocardial damage associated with arrhythmogenic right ventricular cardiomyopathy, the null points of the RV myocardium have not been assessed on contrast-enhanced IR MR imaging. In this study, the null points of the RV and left ventricular (LV) myocardia were evaluated using an IR fast multi-shot echo-planar imaging (Look-Locker sequence) in 26 patients with various cardiac diseases. In nine of the 26 patients, the null points of the RV myocardium were shorter than those of the LV myocardium in the Look-Locker sequence. The RV myocardial signals were significantly higher than the LV myocardial signals in delayed contrast-enhanced MR images. Thus, more attention should be paid to evaluation of the late enhancement of the RV myocardium, and delayed contrast-enhanced MR imaging with a shorter inversion time may be required in some cases.
Related Concept Videos
Imaging Studies for Cardiovascular System IV: CMRI
Magnetic Resonance Imaging
Imaging Studies for Cardiovascular System II:Types of Echocardiography
Types of Echocardiography
Transthoracic Echocardiography (TTE)
TTE is the most common type of echocardiogram which involves placing a transducer on the patient's chest, emitting sound waves to create heart images. TTE is invaluable for evaluating the heart's size, structure, and motion, making it particularly useful for diagnosing...
Mitral Stenosis II: Clinical features and Diagnostic Tests
Aortic Regurgitation II: Clinical Features and Diagnostic Tests
Imaging Studies for Cardiovascular System V: CT
