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Published on: May 12, 2023
The influence of pH on the G-quadruplex binding selectivity of perylene derivatives
Wirote Tuntiwechapikul1, Thanachai Taka, Mathilde Béthencourt
1Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiangmai 50200, Thailand. wirote@chiangmai.ac.th
Abstract:
Three new perylene derivatives with branched ionizable side chains were synthesized, and their G-quadruplex binding specificities were compared by spectroscopic and electrophoretic analysis with two well-studied G-quadruplex ligands: PIPER and TmPyP4. The value of pH and consequent charge formation and self-aggregation of these perylene derivatives influences not only the type of G-quadruplex formation, but also the G-quadruplex binding selectivity.
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