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A review finds that the autoreply e-mail function avoids problems of subject allocation concealment
1Department of Allied Health Professions, Faculty of Health, University of Central Lancashire, PR 1 2HE United Kingdom. acunningham@uclan.ac.uk
Background And Objectives:
Using the autoreply e-mail function to avoid problems of subject allocation concealment.
Methods:
A narrative review discussing technologic and methodologic issues in using autoreply e-mail to securely conceal subject allocation in randomized control trials.
Results:
Autoreply e-mail can be successfully used to securely conceal subjects in a variety of randomized control trials.
Conclusions:
The allocation of subjects to intervention groups in randomized controlled trials should be achieved using methods that avoid both systematic bias and subject allocation transparency. The use of computer-generated tables and the automatic e-mail reply system are suggested as a solution to ensuring subject allocation concealment.
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