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Microprocessor controlled transdermal drug delivery.

J Anand Subramony1, Ashutosh Sharma, J B Phipps

  • 1ALZA Corporation, 1900 Charleston Road, Mountain View, CA 94043, USA. asubramo@alzus.jnj.com

International Journal of Pharmaceutics
|May 23, 2006
PubMed
Summary
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Transdermal drug delivery using iontophoresis effectively delivers lidocaine for anesthesia and fentanyl for pain management. Advanced controllers ensure precise dosing and unique features enhance drug delivery capabilities.

Area of Science:

  • Pharmacology
  • Biomedical Engineering
  • Drug Delivery Systems

Background:

  • Transdermal drug delivery offers a non-invasive alternative to traditional administration routes.
  • Iontophoresis utilizes electrical current to enhance drug permeation through the skin.
  • Effective pain management and local anesthesia are critical in clinical practice.

Purpose of the Study:

  • To review transdermal drug delivery via iontophoresis.
  • To highlight the application of iontophoresis for lidocaine and fentanyl delivery.
  • To discuss the role of advanced controller features in iontophoretic systems.

Main Methods:

  • Literature review focusing on iontophoretic transdermal drug delivery.
  • Analysis of iontophoresis applications for local anesthetics (lidocaine) and analgesics (fentanyl).

Related Experiment Videos

  • Examination of microprocessor controller functionalities in iontophoretic devices.

    • Main Results:

    • Iontophoresis is a viable method for transdermal delivery of lidocaine and fentanyl.
    • Microprocessor controllers enable precise dosimetry, polarity control, and programmed/sensor-based delivery.
    • Novel features like tactile signaling and pulsatile waveforms improve iontophoretic systems.

    Conclusions:

    • Iontophoresis represents a significant advancement in transdermal drug delivery for anesthesia and pain control.
    • Advanced control systems are crucial for optimizing iontophoretic drug administration.
    • Future developments may further enhance the efficacy and user control of iontophoretic therapies.