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Updated: Jul 31, 2026
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Minced Tissue in Compressed Collagen: A Cell-containing Biotransplant for Single-staged Reconstructive Repair
Published on: February 24, 2016
Clinical experience with Alloderm: a one-staged composite dermal/epidermal replacement utilizing processed cadaver
R A Callcut1, M J Schurr, M Sloan
1Department of Surgery, University of Wisconsin, 600 Highland Avenue, Madison, WI 53792, USA.
Summary
AlloDerm (allogeneic cellular and acellular keratinocyte sheets) is a feasible option for acute burn management. This study shows successful graft take in most patients requiring skin reconstruction.
Area of Science:
- Regenerative Medicine
- Dermatology
- Plastic Surgery
Background:
- Alloderm (allogeneic cellular and acellular keratinocyte sheets) is proposed for acute burn wound management.
- Limited studies document the clinical feasibility of using Alloderm for burns.
Purpose of the Study:
- To evaluate the feasibility and success rate of Alloderm in managing acute burns and traumatic skin loss.
Main Methods:
- A retrospective review of medical records was conducted for patients treated with Alloderm from 1999 onwards.
- Data collected included patient demographics, wound characteristics, Alloderm application details, and outcomes.
Main Results:
- Alloderm was applied to 21 burn patients and 6 patients with traumatic skin loss.
- Average Alloderm size was 517 cm², thickness 0.008 inches.
- Successful graft take was observed in 26 out of 27 patients, including applications on the face and hands.
Conclusions:
- Alloderm demonstrates successful application and graft take in patients with acute burns and traumatic skin loss.
- This technique is a viable option for skin grafting in complex wound scenarios.
