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Caulerpenyne-colchicine hybrid: synthesis and biological evaluation

Julien Bourdron1, Laurent Commeiras, Pascale Barbier

  • 1UMR-CNRS 6178 SymBio, équipe Synthèse par voie Organométallique, Université Paul Cézanne (Aix-Marseille III), Marseille, France.

Bioorganic & Medicinal Chemistry
|May 23, 2006
PubMed

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Microtubules are dynamic structures and can be regulated by microtubule targeting agents (MTAs). Microtubule destabilizing drugs are a class of MTAs that destabilize and prevent microtubules' polymerization. Both natural and synthetic chemicals can be found under this class of drugs. Vincristine and vinblastine, two vinca alkaloids, and colchicine were among the first to be discovered. These drugs can affect cells in various ways, either by inducing a change in cell morphology, preventing...