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Isolation of a human monoclonal antibody with strong neutralizing activity against diphtheria toxin

Mai Kakita1, Tsuyoshi Takahashi, Takako Komiya

  • 1Institute for Antibodies Ltd., Toyoake, Aichi 470-1192, Japan.

Infection and Immunity
|May 23, 2006
PubMed

We isolated a human monoclonal antibody against diphtheria toxin (DT). It bound to fragment B with a binding activity (Kd) of 3.01 nM. The neutralizing activity assayed by the rabbit skin test was estimated to be 73,600 IU/g. This could be used as a therapeutic drug against DT in place of the traditional equine sera.

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