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High-dose intravenous IgG treatment and renal function

J Schifferli1, M Leski, H Favre

  • 1Division of Nephrology, Hôpital Cantonal Universitaire, Geneva, Switzerland.

Lancet (London, England)
|February 23, 1991
PubMed

In an open trial of high dose intravenous IgG (IVIG) treatment in nephrotic patients with glomerulonephritis, the first six patients so far studied showed a transient rise in plasma creatinine. This increase was not associated with any symptoms and the urinary deposit remained unchanged. Two other patients with pre-existing renal impairment but without nephrotic syndrome had a transient and reversible rise in plasma creatinine immediately after IVIG. These observations suggest that high-dose IVIG infusion can produce short-lived disturbances in renal function in patients with kidney diseases.

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