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Updated: Aug 8, 2026

Synthesis and Assay of Vibrio Quorum Sensing Inhibitors
Published on: May 31, 2024
Presence of LuxS/AI-2 based quorum-sensing system in Vibrio mimicus : luxO controls protease activity
Zafar Sultan1, Shin-ichi Miyoshi, Sumio Shinoda
1Graduate School of Natural Science and Technology, Okayama University, Tsushima-Naka, Japan. zafar@pharm.okayama-u.ac.jp
Abstract:
Presence of the quorum-sensing regulation system in Vibrio mimicus was investigated. The culture supernatants of V. mimicus strains were found to possess AI-2 autoinducer like activity, and the strains were found to harbor the genes which are homologous to luxS, luxO, and luxR of V. harveyi. These genes of V. harveyi have been shown to be important components of V. harveyi-like quorum-sensing system. The luxO gene homologue known to encode LuxO, the central component of the regulation system, was disrupted, and effects on protease and hemolysin activity were studied. Disruption of luxO gene resulted in the increased protease activity, but the hemolysin activity did not vary considerably.
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