Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Purinergic signalling in neuron-glia interactions.

R Douglas Fields1, Geoffrey Burnstock

  • 1National Institute of Child Health and Human Development, National Institutes of Health, Building 35, Room 2A211, MSC 3713, 35 Lincoln Drive, Bethesda, Maryland 20892, USA. fieldsd@mail.nih.gov

Nature Reviews. Neuroscience
|May 23, 2006
PubMed
Summary

Adenosine triphosphate (ATP) released by neural cells activates purinergic receptors, enabling glial cells to detect and communicate neural activity. This purinergic signaling regulates crucial cellular functions and interactions within the nervous system.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Non-Synaptic Mechanism of Ocular Dominance Plasticity.

ASN neuro·2026
Same author

The Concise Guide to PHARMACOLOGY 2025/26: G protein-coupled receptors.

British journal of pharmacology·2025
Same author

Non-synaptic Mechanism of Ocular Dominance Plasticity.

bioRxiv : the preprint server for biology·2025
Same author

Connectivity in the Human Cerebral Cortex: A Fundamental Problem and a Possible Explanation for the Cognitive Power of Vertebrates.

The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry·2025
Same author

G-Ratio Commentary-Why You've Been Doing It Wrong.

ASN neuro·2025
Same author

Recovery of node of ranvier structure in optic nerve under visual deprivation.

Neuroscience research·2024

Area of Science:

  • Neuroscience
  • Cell Biology
  • Biochemistry

Background:

  • Activity-dependent release of adenosine triphosphate (ATP) from neurons and glia activates purinergic receptors.
  • This purinergic signaling modulates intracellular calcium and cyclic adenosine monophosphate (cAMP) levels.
  • Glia utilize ATP release to detect neural activity and communicate with other glial cells.

Purpose of the Study:

  • To review the involvement of ATP and adenosine receptors in neuron-glia signaling.
  • To discuss the release and hydrolysis of ATP, receptor signaling mechanisms, and pharmacological tools.
  • To highlight the functional significance of purinergic signaling in the nervous system.

Main Methods:

  • Literature review of studies on purinergic signaling in neuron-glia communication.

Related Experiment Videos

  • Analysis of ATP release mechanisms (channels and vesicles).
  • Examination of purinergic receptor signaling pathways and their modulation of cellular functions.

    • Main Results:

    • Purinergic signaling regulates glial proliferation, motility, survival, differentiation, and myelination.
    • It facilitates interactions between neurons, vascular cells, and immune cells.
    • Interactions with growth factor and cytokine signaling impact synaptic strength, development, and injury response.

    Conclusions:

    • ATP and adenosine receptors are critical mediators of neuron-glia communication.
    • Purinergic signaling plays a vital role in maintaining nervous system function, development, and repair.
    • Understanding these pathways offers therapeutic potential for neurological disorders.