Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Metabonomics techniques and applications to pharmaceutical research & development.

John C Lindon1, Elaine Holmes, Jeremy K Nicholson

  • 1Biological Chemistry, Biomedical Sciences Division, Imperial College London, Sir Alexander Fleming Building, South Kensington, London, SW7 2AZ, UK. j.lindon@imperial.ac.uk

Pharmaceutical Research
|May 23, 2006
PubMed
Summary

Metabonomics, the study of metabolic responses to physiological or pathological stimuli, offers powerful analytical and statistical techniques. This approach has significant applications in pharmaceutical R&D, drug safety, disease diagnosis, and personalized medicine.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

High adherence to a Mediterranean diet is associated with a diverse faecal microbiome and reduced systemic inflammation in a cohort of pregnant women.

Scientific reports·2026
Same author

Metabolic pathways associated with cardiometabolic risk effects on cognition in middle-aged adults: the CARDIA study.

Metabolomics : Official journal of the Metabolomic Society·2026
Same author

Sex-based differences in long-term lipid metabolism, inflammation, and stress regulation after non-severe paediatric burns.

Burns : journal of the International Society for Burn Injuries·2026
Same author

Metabolism and Excretion of Synthetic Extended Viperin Pathway Deoxydidehydronucleosides in the Sprague-Dawley Rat.

Journal of proteome research·2026
Same author

Methoxyacetic acid exposure in rats induces N-butyrylglycinuria consistent with beta-oxidation impairment.

Archives of toxicology·2026
Same author

Disordered Bile Acid Metabolism in Alcohol-Related Hepatitis.

Alimentary pharmacology & therapeutics·2026

Area of Science:

  • Biochemistry and Systems Biology
  • Analytical Chemistry
  • Pharmacology

Background:

  • Metabonomics provides a systems-level understanding of biological responses.
  • It involves comprehensive analysis of small molecule metabolites.
  • Historical perspective and evolution of analytical and statistical methods are discussed.

Purpose of the Study:

  • To review the background, techniques, and applications of metabonomics.
  • To highlight its relevance in pharmaceutical research and development.
  • To discuss its potential in drug safety, disease diagnosis, and personalized medicine.

Main Methods:

  • Review of analytical techniques (e.g., NMR, mass spectrometry).
  • Summary of statistical methods for data analysis.

Related Experiment Videos

  • Case studies and examples from literature.

    • Main Results:

    • Metabonomics aids in understanding metabolic influences (diet, environment).
    • Applications in drug safety studies, exemplified by the Consortium for Metabonomic Toxicology.
    • Potential for disease diagnosis, therapy monitoring, and pharmacometabonomics.

    Conclusions:

    • Metabonomics is a valuable tool in pharmaceutical R&D and personalized medicine.
    • It offers insights into biological responses to various stimuli.
    • Discussion of the future prospects, including strengths, weaknesses, opportunities, and threats.