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Solid-state characterization of buspirone hydrochloride polymorphs.

M Sheikhzadeh1, S Rohani, A Jutan

  • 1Department of Chemical and Biochemical Engineering, The University of Western Ontario, London, Ontario N6A 5B9, Canada.

Pharmaceutical Research
|May 23, 2006
PubMed
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This study characterized two forms of buspirone hydrochloride, an anxiolytic drug. Techniques like microscopy, thermal analysis, FTIR, and XRPD differentiated the crystalline forms, aiding in quality control.

Area of Science:

  • Solid-state chemistry
  • Pharmaceutical analysis
  • Materials science

Background:

  • Buspirone hydrochloride is an anxiolytic medication.
  • Understanding its polymorphic forms (Form 1 and Form 2) is crucial for pharmaceutical development and quality control.

Purpose of the Study:

  • To comprehensively characterize Form 1 and Form 2 of buspirone hydrochloride.
  • To evaluate various analytical techniques for distinguishing and quantifying these polymorphic forms.

Main Methods:

  • Microscopy (optical, hot stage, scanning electron microscopy)
  • Thermal analysis (differential scanning calorimetry, thermogravimetric analysis)
  • Spectroscopy (FTIR, Raman)
  • X-ray powder diffractometry (XRPD)

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Main Results:

  • Form 1 exhibited plate crystals, while Form 2 showed columnar crystals, both with good filterability.
  • The two forms were found to be enantiotropic.
  • FTIR and Raman spectroscopy effectively differentiated the polymorphs, with XRPD proving useful for both qualitative and quantitative analysis.

Conclusions:

  • Multiple analytical techniques can successfully characterize buspirone hydrochloride polymorphs.
  • XRPD is a powerful tool for polymorphic identification and quantification.
  • This characterization aids in ensuring the quality and consistency of buspirone hydrochloride formulations.