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Updated: Aug 8, 2026
08:16
Optogenetic Activation of Afferent Pathways in Brain Slices and Modulation of Responses by Volatile Anesthetics
Published on: July 23, 2020
[Organ protection by anesthetics: preface and comments]
1Department of Anesthesia and Intensive Care, Akita University School of Medicine, Akita 010-8543.
Masui. the Japanese Journal of Anesthesiology
|May 24, 2006
Summary
Anesthetics, once primarily studied for toxicity, are now known to offer organ protection against ischemia and reperfusion injury. Recent research highlights their beneficial roles in preconditioning and cell death mechanisms.
Area of Science:
- Anesthesiology
- Cell Biology
- Organ Physiology
Context:
- For over 40 years, research on anesthetics primarily focused on their toxicity, such as hepatotoxicity and nephrotoxicity.
- Recent basic research has revealed beneficial effects of anesthetics, challenging the traditional view.
- Understanding anesthetic mechanisms is crucial for clinical applications in organ protection.
Purpose:
- To present new findings on the protective effects of anesthetics on vital organs.
- To elucidate the mechanisms behind anesthetic preconditioning and cell death.
- To consolidate expert knowledge on anesthetic-induced organ protection.
Summary:
- Anesthetics demonstrate beneficial effects, including organ protection against ischemia-reperfusion injury and anesthetic preconditioning.
- Mechanisms of acute and delayed cell death, including apoptosis, have been clarified.
- This special issue compiles expert insights on anesthetic protection for the brain, heart, lung, and liver.
Impact:
- Shifts the paradigm of anesthetic research from toxicity to therapeutic potential.
- Provides a comprehensive overview of anesthetic organ protection mechanisms.
- Informs clinical practice by highlighting the protective roles of anesthetics in various organs.
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