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Related Experiment Videos

Platelet function in humans is not altered by hyperbaric oxygen therapy.

S R Thom1, D Fisher, J M Stubbs

  • 1Department of Emergency Medicine, University of Pennsylvania Medical Center, 3620 Hamilton Walk, Philadelphia, PA 19104-6068, USA.

Undersea & Hyperbaric Medicine : Journal of the Undersea and Hyperbaric Medical Society, Inc
|May 24, 2006
PubMed
Summary

Hyperbaric oxygen therapy did not significantly alter platelet function in patients receiving it to prevent osteoradionecrosis. This pilot study found no changes in platelet aggregation, ATP release, or integrin expression after treatments.

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Area of Science:

  • Hyperbaric medicine
  • Hematology
  • Oncology

Background:

  • Osteoradionecrosis is a serious complication of radiation therapy.
  • Hyperbaric oxygen therapy (HBOT) is used for prophylaxis and treatment of osteoradionecrosis.
  • Platelet function may be affected by HBOT, potentially influencing treatment outcomes.

Purpose of the Study:

  • To investigate the effects of HBOT on platelet function in patients undergoing prophylaxis for osteoradionecrosis.
  • To assess changes in platelet aggregation, adenosine triphosphate (ATP) release, and activated alpha-IIb/beta-3 integrin expression.

Main Methods:

  • A pilot study involving 6 patients undergoing HBOT (2.0 ATA O2, 2 hours/day, 6 days/week).
  • Blood samples were collected before and after the 1st, 10th, and 20th HBOT sessions.

Related Experiment Videos

  • Platelet aggregation, ATP release, and alpha-IIb/beta-3 integrin expression were measured.

    • Main Results:

    • No significant changes were observed in platelet aggregation following HBOT.
    • Adenosine triphosphate (ATP) release from platelets remained unchanged.
    • Expression of activated alpha-IIb/beta-3 integrin on platelets showed no significant difference.

    Conclusions:

    • This pilot study suggests that HBOT, under the tested conditions, does not significantly impact key markers of platelet function.
    • Further research with larger cohorts may be warranted to confirm these findings in patients undergoing HBOT for osteoradionecrosis prophylaxis.