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Related Experiment Videos

Holeboard discrimination learning in mice.

K A Kuc1, B M Gregersen, K S Gannon

  • 1Eli Lilly and Company, Neuroscience Discovery Research, Indianapolis, IN 46285, USA.

Genes, Brain, and Behavior
|May 24, 2006
PubMed
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Researchers developed a new mouse spatial learning task to assess working and reference memory. This holeboard task effectively measures memory in different mouse strains and under drug treatments.

Area of Science:

  • Neuroscience
  • Behavioral Neuroscience
  • Animal Models

Background:

  • Spatial memory is crucial for survival and is impaired in various neurological conditions.
  • Existing tasks for assessing spatial memory in mice have limitations.
  • A need exists for a versatile and reliable spatial memory assessment tool in mice.

Purpose of the Study:

  • To adapt and validate a holeboard-learning task for simultaneous assessment of spatial working and reference memory in mice.
  • To evaluate the task's sensitivity to different mouse strains, learning rates, and pharmacological interventions.
  • To investigate the task's utility in characterizing memory deficits in transgenic mouse models.

Main Methods:

  • Adaptation of a 16-hole board apparatus for spatial learning in mice.

Related Experiment Videos

  • Training protocols involving varying trials per day (4-6) to assess acquisition rates.
  • Administration of scopolamine (a muscarinic antagonist) to evaluate pharmacological effects on learning.
  • Testing of amyloid precursor protein transgenic mice to assess working memory during reversal learning.

    • Main Results:

    • C57BL/6 mice acquired the task within 4-8 days, demonstrating efficient learning.
    • Multiple mouse strains (C57BL/6, Swiss-Webster, CD-1, DBA/2) showed similar acquisition patterns.
    • Scopolamine disrupted learning at 0.1 and 1.0 mg/kg, with potential side-effects at higher doses.
    • Amyloid precursor protein transgenic mice exhibited selective working memory deficits during reversal training.

    Conclusions:

    • The adapted holeboard task is a robust and sensitive tool for assessing spatial working and reference memory in mice.
    • The task is suitable for evaluating spatial memory across different mouse strains and in response to genetic or pharmacological manipulations.
    • This validated task provides a valuable platform for preclinical research into memory disorders.