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Published on: April 24, 2021
CHOP is involved in neuronal apoptosis induced by neurotrophic factor deprivation
Seiji Tajiri1, Shigetoshi Yano, Motohiro Morioka
1Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Japan.
Abstract:
Neurotrophic factors are essential for the survival of neurons. We found that the endoplasmic reticulum (ER) stress-C/EBP homologues protein (CHOP) pathway to be activated during neurotrophic factor deprivation-induced apoptosis in PC12 neuronal cells and in primary cultured neurons, and this apoptosis was suppressed in the neurons from chop(-/-) mice. In addition, we found that CHOP is expressed in the subventricular zone (SVZ) and striatum of the young adult mouse brain. The number of apoptotic cells in the SVZ decreased in chop(-/-) mice. These results indicate that the ER stress-CHOP pathway plays a role in neuronal apoptosis during the development of the brain.
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