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[Rhabdomyolysis induced by fenofibrate monotherapy].

F Archambeaud-Mouveroux1, S Lopez, C Combes

  • 1Service de Médecine Interne B-d'Endocrinologie, Hôpital du Cluzeau, 23, avenue Dominique-Larrey, 87042 Limoges, France. francoise.archambeaud@chu-limoges.fr

La Revue De Medecine Interne
|May 24, 2006
PubMed
Summary
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Rhabdomyolysis, a serious muscle condition, can occur with fibrate medications. This case highlights a potential drug interaction between fenofibrate and gliclazide in a diabetic patient, leading to rhabdomyolysis.

Area of Science:

  • Pharmacology
  • Toxicology
  • Endocrinology

Background:

  • Fibrates are known to cause rhabdomyolysis, particularly when co-administered with statins, in patients with renal insufficiency, or hypothyroidism.
  • This highlights the potential for drug-induced myotoxicity with fibrate therapy.

Observation:

  • A patient with diabetes mellitus, previously managed with fenofibrate monotherapy for years, developed rhabdomyolysis.
  • The adverse event occurred within 48 hours of initiating gliclazide therapy.

Findings:

  • The case suggests a potential drug interaction between fenofibrate and gliclazide as a cause of rhabdomyolysis.
  • Dehydration may have also contributed to the development of this condition.

Implications:

Related Experiment Videos

  • This case underscores the importance of monitoring for myotoxicity when combining fibrates with other glucose-lowering agents like gliclazide.
  • Clinicians should consider potential drug interactions and patient-specific factors such as dehydration when prescribing fibrates.