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Biomedical sensor using thick film technology for transcutaneous oxygen measurement.

Yu-Zhi Lam1, John K Atkinson

  • 1School of Engineering Sciences, University of Southampton, Highfield, Southampton SO17 1BJ, United Kingdom. LL2004@alumni.soton.ac.uk

Medical Engineering & Physics
|May 24, 2006
PubMed
Summary

This study developed a low-cost, disposable transcutaneous oxygen sensor for monitoring respiratory conditions. The screen-printed sensor, using amperometry and a heating element, showed linear and repeatable results in lab tests and a pilot clinical trial.

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Area of Science:

  • Biomedical Engineering
  • Sensor Technology
  • Respiratory Monitoring

Background:

  • Transcutaneous blood gas monitoring offers a non-invasive method for assessing patient respiratory status.
  • Existing methods require accurate and rapid response for effective patient management.

Purpose of the Study:

  • To develop and evaluate a novel, screen-printed, disposable transcutaneous oxygen sensor.
  • To assess the sensor's performance using amperometry and an integrated heating element for enhanced blood gas diffusion.

Main Methods:

  • A Clark cell configuration with gold electrodes and a Ag/AgCl reference electrode was utilized.
  • Two electrolytes (potassium nitrate gel and Nafion) were tested under controlled laboratory conditions.
  • A computer-controlled gas testing rig was employed for automated oxygen level variation and a pilot clinical trial was conducted.

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Main Results:

  • Linear relationships were established with an average sensitivity of 0.029 microA/mmHg in laboratory tests.
  • The thick film sensor demonstrated repeatable and linear correlations with a commercial transcutaneous blood gas analyzer in a pilot clinical trial.
  • Measured signals in the clinical trial were weaker than laboratory results, but consistency was maintained.

Conclusions:

  • The developed thick film sensor shows promise as a viable, low-cost biomedical sensor for transcutaneous oxygen monitoring.
  • The study contributes to understanding material suitability for effective non-invasive respiratory monitoring.
  • Further development could optimize signal strength for broader clinical application.