Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Renal urate transport.

David B Mount1, Charles Y Kwon, Kambiz Zandi-Nejad

  • 1Harvard Medical School, Boston, MA, USA. dmount@rics.bwh.harvard.edu

Rheumatic Diseases Clinics of North America
|May 24, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

<i>Ex vivo</i> quantification of intracellular pH in <i>Drosophila</i> Malpighian tubule reveals basolateral HCO<sub>3</sub> <sup>-</sup>/oxalate exchange through a novel oxalate transporter "Neat".

Frontiers in physiology·2025
Same author

Innovating Kidney Care in Patients with Cancer: Development of an Inpatient Onconephrology Service.

Clinical journal of the American Society of Nephrology : CJASN·2025
Same author

Undetected Air Embolism During Hemodialysis from a Defective Central Venous Catheter Causing Intradialytic Cardiac Arrest: An Imaging Teaching Case.

Kidney medicine·2024
Same author

Yet More Reassurance: Treat-to-Target With Allopurinol or Febuxostat is Safe and Effective in Lowering Serum Urate in People With CKD.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2024
Same author

Controversies and practical management of patients with gout and chronic kidney disease.

Kidney international·2024
Same author

Caffeine Inhibits Both Basal and Insulin-Activated Urate Transport.

Arthritis & rheumatology (Hoboken, N.J.)·2024
Same journal

Bridging the Divide in Global Rheumatology.

Rheumatic diseases clinics of North America·2026
Same journal

Foreword.

Rheumatic diseases clinics of North America·2026
Same journal

Pulmonary Complications of Biological Therapies in Inflammatory and Autoimmune Diseases.

Rheumatic diseases clinics of North America·2026
Same journal

Artificial Intelligence and Social Determinants of Health.

Rheumatic diseases clinics of North America·2026
Same journal

Updates in Ultrasound in Rheumatology.

Rheumatic diseases clinics of North America·2026
Same journal

Health Systems Strengthening to Promote Access to Care for Rheumatic and Musculoskeletal Diseases Globally.

Rheumatic diseases clinics of North America·2026
See all related articles

Serum uric acid levels are regulated by kidney excretion and production. Increased levels of certain anions, like lactate and ketoacids, can stimulate urate reabsorption, leading to hyperuricemia.

Area of Science:

  • Nephrology
  • Renal Physiology
  • Molecular Biology

Background:

  • Serum uric acid homeostasis relies on renal excretion and production.
  • Proximal tubule reabsorption of urate involves sodium-anion cotransport and urate-anion exchange.
  • Elevated plasma anions can disrupt urate balance.

Purpose of the Study:

  • To review developments in the molecular and renal physiology of urate homeostasis.
  • To explain the mechanism of urate reabsorption in the proximal tubule.
  • To elucidate the link between anion levels and hyperuricemia.

Main Methods:

  • Review of molecular and physiological studies on urate transport.
  • Analysis of the role of sodium-anion cotransport in proximal tubular cells.

Related Experiment Videos

  • Examination of the urate-anion exchange mechanism.

    • Main Results:

    • Apical sodium-coupled cotransport of lactate, ketoacids, nicotinate, and pyrazinoate enhances intracellular anion levels.
    • Increased intracellular anions stimulate apical urate absorption via anion exchange.
    • Hyperuricemia is associated with elevated plasma levels of these anions, as seen in lactic acidosis and ketoacidosis.

    Conclusions:

    • The proximal tubule plays a critical role in regulating serum uric acid.
    • Anion cotransport mechanisms directly influence urate reabsorption.
    • Understanding these pathways is key to managing hyperuricemia and related conditions.