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Updated: Aug 8, 2026
10:03
Swab Sampling Method for the Detection of Human Norovirus on Surfaces
Published on: February 6, 2017
Norovirus outbreak in a pediatric oncology unit
Arne Simon1, Oliver Schildgen, Anna Maria Eis-Hübinger
1Pediatric Hematology and Oncology, Children's Hospital, University of Bonn, Bonn, Germany. asimon@ukb.uni-bonn.de
Scandinavian Journal of Gastroenterology
|May 24, 2006
Summary
Norovirus (NV) outbreaks in pediatric oncology units can cause severe illness. Patients may shed the virus for months, requiring prolonged isolation and close monitoring for complications.
Area of Science:
- Infectious Diseases
- Pediatric Oncology
- Virology
Background:
- Norovirus (NV) is a significant cause of epidemic gastroenteritis in healthcare settings.
- Immunocompromised patients, such as those in pediatric oncology units, are at high risk for severe NV infection.
Purpose of the Study:
- To describe a Norovirus outbreak in a pediatric oncology unit.
- To discuss the consequences of NV infection in this vulnerable population.
Main Methods:
- Stool and vomitus samples from 11 patients were tested for NV using RT-PCR and ELISA.
- Phylogenetic analysis was performed on Norovirus PCR amplifications.
Main Results:
- The index patient and transmission chain were identified.
- Viral shedding lasted up to 140 days (median 23 days).
- Three patients developed severe or life-threatening symptoms.
Conclusions:
- Prompt NV testing is crucial for gastroenteritis outbreaks in pediatric oncology units.
- Prolonged isolation may be necessary until diagnostic assays are negative.
- Close monitoring is essential due to prolonged shedding and risk of severe complications.
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