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qPCR Is a Sensitive and Rapid Method for Detection of Cytomegaloviral DNA in Formalin-fixed, Paraffin-embedded Biopsy Tissue
Published on: July 9, 2014
Cytomegalovirus infection in ulcerative colitis
Tetsu Kojima1, Toshiaki Watanabe, Keisuke Hata
1Department of Surgical Oncology, University of Tokyo Graduate School of Medicine, Tokyo, Japan. kojimat-tky@umin.ac.jp
Scandinavian Journal of Gastroenterology
|May 24, 2006
Summary
Cytomegalovirus (CMV) infection is more common in severe ulcerative colitis (UC) than refractory UC or UC-associated cancer. Older age is a risk factor for CMV infection in severe UC patients.
Area of Science:
- Gastroenterology
- Virology
- Surgical Pathology
Background:
- Cytomegalovirus (CMV) infection is implicated in inflammatory bowel disease exacerbation, but its role in ulcerative colitis (UC) requires further elucidation.
- Clinicopathologic features of CMV infection in UC surgical specimens are not well-defined.
Purpose of the Study:
- To investigate the clinicopathologic features of CMV infection in UC patients undergoing colectomy.
- To determine the prevalence and risk factors of CMV infection in different UC severity groups.
Main Methods:
- Analysis of surgical specimens from UC patients categorized into severe, refractory, and UC-associated dysplasia/cancer groups.
- Evaluation of CMV infection rates and comparison of clinical parameters between CMV-positive and negative patients.
- Multivariate analysis to identify independent risk factors for CMV infection.
Main Results:
- CMV infection was detected in 25% of severe UC patients and 8.3% of refractory UC patients.
- No CMV infection was found in UC-associated dysplasia or cancer cases.
- Older age at operation was significantly associated with CMV positivity in severe UC and identified as an independent risk factor.
Conclusions:
- CMV infection is more prevalent in severe UC compared to refractory UC and UC-associated cancer/dysplasia.
- Advanced age is a significant risk factor for CMV infection in severe UC.
- High-dose steroid use was not consistently identified as a risk factor for CMV infection in this cohort.
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