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Semi-quantitative Assessment Using [18F]FDG Tracer in Patients with Severe Brain Injury
Published on: November 9, 2018
Metabolism and nutrition in patients with moderate and severe traumatic brain injury: A systematic review
Karolina Krakau1, Marianne Omne-Pontén, Torbjörn Karlsson
1Centre for Clinical Research Dalarna, Dummy institution, Sweden. karolina.krakau@ds.se
Primary Objective:
To examine the evidence on the metabolic state and nutritional treatment of patients with moderate-to-severe traumatic brain injury (TBI).
Research Design:
A systematic review of the literature.
Methods And Procedures:
From 1547 citations, 232 articles were identified and retrieved for text screening. Thirty-six studies fulfilled the criteria and 30 were accepted for data extraction.
Main Outcomes And Results:
Variations in measurement methods and definitions of metabolic abnormalities hampered comparison of studies. However, consistent data demonstrated increased metabolic rate (96-160% of the predicted values), of hypercatabolism (-3 to -16 g N per day) and of upper gastrointestinal intolerance in the majority of the patients during the first 2 weeks after injury. Data also indicated a tendency towards less morbidity and mortality in early fed patients.
Conclusions:
The impact of timing, content and ways of administration of nutritional support on neurological outcome after TBI remains to be demonstrated.
