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Updated: Aug 8, 2026

Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds
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An S-nitrosothiol (SNO) synthase function of hemoglobin that utilizes nitrite as a substrate

Michael Angelo1, David J Singel, Jonathan S Stamler

  • 1Department of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA.

Proceedings of the National Academy of Sciences of the United States of America
|May 24, 2006
PubMed
Summary

Red blood cells regulate blood vessel tone via nitric oxide (NO) interactions with hemoglobin (Hb). This study reveals Hb’s intrinsic S-nitrosothiol synthase activity, crucial for NO bioactivity and impaired in hypoxemic diseases.

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