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Updated: Aug 8, 2026

A Rat Model of Pouchitis Following Proctocolectomy and Ileal Pouch-Anal Anastomosis Using Dextran Sulfate Sodium
Published on: May 31, 2024
Postoperative joint symptoms: a risk factor for pouchitis in ulcerative colitis patients
Mitsuhiro Nakamura1, Hiroki Ikeuchi, Hiroki Nakano
1Second Department of Surgery, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan.
Background:
The prevalence and significance of joint symptoms appearing in patients with ulcerative colitis (UC) following a colectomy are unclear.
Aim:
We investigated the relationship between joint symptoms during steroid tapering following an ileal pouch-anal anastomosis (IPAA) and the cumulative risk for developing pouchitis.
Patients And Methods:
The medical records of 571 patients who underwent an IPAA with a mucosectomy were retrospectively reviewed to evaluate their joint symptoms. A diagnosis of pouchitis was obtained using the Pouchitis Disease Activity Index (PDAI) and the cumulative risk of pouchitis was estimated using a Kaplan-Meier life table analysis.
Results:
Joint symptoms during steroid tapering were reported by 126 (22.0%) of the UC patients and each of those had involvement of the small joints of the hand. The main symptoms were pain and stiffness, especially in the morning. The cumulative risk for developing pouchitis after 10 years was found to be 20% in patients who experienced joint symptoms during steroid tapering and 10% in those without those symptoms (p = 0.001).
Conclusion:
The presence of joint symptoms during steroid tapering is a significant risk factor for the development of pouchitis in patients who have undergone an IPAA for UC.
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