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Erythrocyte oxidant/antioxidant status in essential hyperhidrosis
Semsettin Karaca1, Mustafa Kulac, Efkan Uz
1Department of Dermatology, School of Medicine, Kocatepe University, Afyonkarahisar, Turkey. skaraca@aku.edu.tr
Molecular and Cellular Biochemistry
|May 24, 2006
Summary
Oxidative stress may contribute to essential hyperhidrosis (EH). Patients with EH showed higher malondialdehyde (MDA) and superoxide dismutase (SOD) levels, but lower catalase (CAT) and glutathione peroxidase (GSH-Px) activities, indicating impaired antioxidant defense.
Area of Science:
- Biochemistry
- Physiology
- Dermatology
Background:
- Essential hyperhidrosis (EH) involves excessive sweating without a clear cause.
- Nitric oxide (NO) and reactive oxygen species (ROS) may influence sweat production and sympathetic nervous system activity.
Purpose of the Study:
- To investigate the role of oxidative stress in the pathogenesis of essential hyperhidrosis.
- To compare levels of oxidative stress markers and antioxidant enzyme activities in EH patients versus healthy controls.
Main Methods:
- Assessed red blood cell malondialdehyde (MDA) levels and activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT).
- Compared these markers between 31 patients with essential hyperhidrosis and 28 healthy controls.
Main Results:
- Patients with EH exhibited significantly higher erythrocyte SOD activity and MDA levels (p=0.020, p=0.004).
- Conversely, CAT and GSH-Px activities were significantly lower in EH patients (p=0.0001, p=0.0001).
Conclusions:
- Findings suggest increased oxidative damage due to elevated ROS production in essential hyperhidrosis.
- An insufficient antioxidant defense capacity may play a role in the development of EH.