Related Experiment Video
Updated: Aug 8, 2026
09:52
Generation of High Quality Chromatin Immunoprecipitation DNA Template for High-throughput Sequencing (ChIP-seq)
Published on: April 19, 2013
Association between functional FABP2 promoter haplotype and type 2 diabetes
Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme
|May 24, 2006
Summary
Fatty acid-binding protein 2 (FABP2) promoter variants may influence type 2 diabetes risk, particularly in males. Specific FABP2 promoter haplotypes were associated with a reduced risk of developing type 2 diabetes.
Area of Science:
- Genetics and Molecular Biology
- Metabolic Diseases
- Human Physiology
Background:
- Fatty acid-binding protein 2 (FABP2) is crucial in intestinal fatty acid metabolism.
- Previous studies suggest a link between FABP2 genetic variants and type 2 diabetes (T2D).
- FABP2 promoter polymorphisms have been associated with lipid metabolism and body composition.
Purpose of the Study:
- To investigate the association between FABP2 promoter variants and the risk of type 2 diabetes mellitus.
- To explore potential interactions between FABP2 promoter haplotypes and the Ala54Thr polymorphism in T2D susceptibility.
Main Methods:
- Identified FABP2 promoter single nucleotide polymorphisms (SNPs) and insertion-deletion polymorphisms in a Caucasian population.
- Defined FABP2 promoter haplotypes (A and B) based on linkage disequilibrium.
- Conducted a prospective case-control study using the EPIC-Potsdam cohort (192 T2D cases, 384 controls).
- Analyzed the association of FABP2 variants with T2D risk, adjusting for BMI and other covariates.
Main Results:
- FABP2 promoter haplotype B was significantly associated with a decreased risk of type 2 diabetes in male subjects.
- This protective effect was independent of BMI and other covariates.
- The association remained significant even after adjusting for the FABP2 Ala54Thr polymorphism, suggesting a distinct role for promoter variants.
- No association was found between FABP2 variants and BMI, body fat, leptin, HbA1c, total cholesterol, or HDL.
Conclusions:
- Functional FABP2 promoter haplotypes may play a role in type 2 diabetes pathogenesis.
- The association appears to be sex-specific, with a protective effect observed in males.
- These findings highlight the importance of genetic variations in FABP2 in the context of metabolic disease risk.
Related Concept Videos
01:26Type II Diabetes I: Introduction
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance, in which target tissues such as the liver, muscle, and adipose tissue respond poorly to insulin. It is also associated with inadequate compensatory insulin secretion, where pancreatic β-cells fail to produce sufficient insulin. Together, these abnormalities lead to persistent hyperglycemia.EtiologyT2DM develops through a complex interaction of genetic predisposition and environmental or...
01:24Type II Diabetes II: Pathophysiology
PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.
01:22Diabetes Mellitus: Type 2 and Gestational
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
01:26Type I Diabetes II: Pathophysiology
Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular uptake of...
01:25Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis
Type 2 diabetes mellitus develops gradually and is often asymptomatic in early stages.Clinical ManifestationsWhen symptoms appear, they include fatigue, blurred vision, pruritus, delayed wound healing, and recurrent infections, particularly candidal infections. Peripheral neuropathy may present as numbness or tingling in the extremities. Classic hyperglycemia symptoms—polyuria, polydipsia, and polyphagia—are less common. Most patients are overweight and frequently have associated hypertension...
01:12Type I Diabetes I: Introduction
Type 1 diabetes mellitus is a chronic metabolic disorder characterized by an absolute deficiency of insulin resulting from the autoimmune destruction of pancreatic β-cells. Although it can occur at any age, it is most commonly diagnosed in childhood, adolescence, or early adulthood. The loss of insulin production impairs cellular glucose uptake, resulting in persistent hyperglycemia and necessitating lifelong insulin therapy.Autoimmune Destruction of β-CellsThe hallmark of type 1 diabetes is an...