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Related Experiment Videos

Circulating progesterone and obesity in men.

S Blanchette1, P Marceau, S Biron

  • 1Molecular Endocrinology Research Center, Laval University Medical Research Center, Quebec, Canada.

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme
|May 24, 2006
PubMed
Summary

Obese men have lower plasma progesterone levels, which correlate with increased body mass index and waist circumference. Dehydroepiandrosterone sulfate (DHEA-S) is the best steroid predictor of progesterone, suggesting altered adrenal steroid production in obesity.

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Area of Science:

  • Endocrinology
  • Metabolic Health
  • Andrology

Background:

  • Progesterone is present in male plasma, primarily attributed to adrenal origin.
  • Obesity is a growing health concern with complex hormonal associations.
  • The relationship between male obesity and circulating progesterone requires further investigation.

Purpose of the Study:

  • To investigate the association between circulating progesterone levels and obesity markers in men.
  • To explore correlations between progesterone and other key steroid hormones in relation to obesity.
  • To identify predictors of plasma progesterone levels in obese and lean men.

Main Methods:

  • Cross-sectional study of 38 men with varying BMI.
  • Measurement of plasma progesterone, 17-hydroxyprogesterone, androstenedione, testosterone, dihydrotestosterone (DHT), and dehydroepiandrosterone sulfate (DHEA-S).

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  • Statistical analysis including correlation and multivariate regression to assess relationships between steroid levels and obesity indicators (BMI, waist circumference, adipocyte diameter).

    • Main Results:

    • Plasma progesterone levels showed significant negative correlations with body weight, BMI, waist circumference, and subcutaneous adipocyte diameter.
    • Other androgens (17-OH-progesterone, DHEA-S, androstenedione, testosterone, DHT) also negatively correlated with obesity markers.
    • Plasma DHEA-S was the strongest steroid correlate of progesterone, and waist circumference was the best overall predictor in multivariate models.

    Conclusions:

    • Plasma progesterone is negatively associated with obesity indicators in men.
    • Low progesterone levels in obese men may indicate reduced adrenal C(19) steroid production.
    • Further research is warranted to confirm the proposed mechanisms of altered adrenal function in male obesity.