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Related Experiment Videos

Probable interaction between tolterodine and warfarin.

James R Taylor1

  • 1College of Pharmacy, University of Florida, Gainesville, 32610-0486, USA. jtaylor@cop.ufl.edu

Pharmacotherapy
|May 25, 2006
PubMed
Summary
This summary is machine-generated.

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Extended-release tolterodine may increase warfarin

Area of Science:

  • Pharmacology
  • Clinical Pharmacy

Background:

  • Warfarin is a common anticoagulant used to prevent thromboembolic events.
  • Maintaining a stable International Normalized Ratio (INR) is crucial for warfarin efficacy and safety.
  • Overactive bladder is a condition often managed with medications like tolterodine.

Observation:

  • A patient on stable warfarin therapy experienced elevated INR after initiating extended-release tolterodine.
  • Warfarin dosage was reduced prior to tolterodine initiation, yet INR increased.
  • No other contributing factors were identified for the INR elevation.

Findings:

  • A probable drug interaction between extended-release tolterodine and warfarin was identified.
  • Tolterodine's initiation led to a clinically significant increase in INR.

Related Experiment Videos

  • This interaction necessitated a reduction in warfarin dosage.

    • Implications:

    • Concurrent use of tolterodine and warfarin requires careful INR monitoring.
    • Clinicians should anticipate potential warfarin dose adjustments when prescribing tolterodine.
    • This interaction highlights the importance of medication review in patients on anticoagulation.