Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dopamine receptor blockade and extinction differentially affect behavioral variability.

Jacqueline H Rick1, Jon C Horvitz, Peter D Balsam

  • 1Department of Psychology, Columbia University, New York, NY, USA. jacquir@bbl.med.upenn.edu

Behavioral Neuroscience
|May 25, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Automated device for permitting free movement during simultaneous photometry and electrophysiology in mice.

Nature methods·2026
Same author

All cells have the capacity to time.

Journal of experimental psychology. Animal learning and cognition·2026
Same author

Impact of temporal uncertainty on sign-tracking behavior.

Journal of experimental psychology. Animal learning and cognition·2025
Same author

Both probability and rate of reinforcement can affect the acquisition and maintenance of conditioned responses.

Journal of experimental psychology. Animal learning and cognition·2024
Same author

Inhibition of striatal indirect pathway during second postnatal week leads to long-lasting deficits in motivated behavior.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2024
Same author

Learning depends on the information conveyed by temporal relationships between events and is reflected in the dopamine response to cues.

Science advances·2024
Same journal

Hippocampal communication with the anterior olfactory nucleus is necessary for context-dependent odor memory.

Behavioral neuroscience·2026
Same journal

Biological sex and normative cognitive aging across spatial learning, flexibility, and working memory in Fischer 344 rats.

Behavioral neuroscience·2026
Same journal

Defensive antinociception and antipredatory responses in prey threatened by distinct odoriferous cues from Felis silvestris catus.

Behavioral neuroscience·2026
Same journal

Taste exposure during different developmental phases impacts aversion learning in adult rats.

Behavioral neuroscience·2026
Same journal

Structural neuroanatomy of semantic retrograde memory in older adults.

Behavioral neuroscience·2026
Same journal

Oxytocin prevents cocaine-induced high-affect 50-kHz vocalizations in female rats.

Behavioral neuroscience·2026
See all related articles

Dopamine receptor blockade suppressed operant responding in rats, similar to reward omission. However, unlike extinction, dopamine antagonists did not increase behavioral variability.

Area of Science:

  • Neuroscience
  • Behavioral Pharmacology

Background:

  • Dopamine (DA) neurons are crucial for reward processing, responding to unexpected rewards and being inhibited by reward omission.
  • Dopamine receptor blockade partially mimics non-reward (extinction) conditions, but its effect on behavioral variability remains unclear.

Purpose of the Study:

  • To investigate whether dopamine receptor blockade increases behavioral variability, similar to extinction, in addition to its known response-suppressing effects.

Main Methods:

  • Rats were trained on an operant task involving key presses for food rewards on a continuous reinforcement schedule.
  • Response rates and behavioral variability were measured.
  • Rats received administration of D(1) and D(2) antagonists (SCH23390 and raclopride) or were subjected to extinction conditions.

Related Experiment Videos

Main Results:

  • Both dopamine receptor antagonists and extinction suppressed operant responding.
  • Unlike extinction, dopamine receptor blockade did not result in an increase in behavioral variability.

Conclusions:

  • Dopamine receptor blockade mimics some, but not all, behavioral effects of reward omission.
  • The increase in behavioral variability observed during extinction is not solely mediated by dopamine receptor activity.