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Updated: Aug 8, 2026
07:23
Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome
Published on: June 15, 2016
Transcriptional regulatory elements in the human genome
Glenn A Maston1, Sara K Evans, Michael R Green
1Howard Hughes Medical Institute, Programs in Gene Function and Expression and Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA. Glenn.Maston@umassmed.edu
Annual Review of Genomics and Human Genetics
|May 25, 2006
Summary
Gene expression relies on precise regulation by various elements and molecular machinery. Understanding these components and methods for identifying them is crucial for biological processes and disease research.
Area of Science:
- Molecular Biology
- Genetics
- Genomics
Background:
- Biological processes require precise gene expression.
- Gene expression depends on spatial and temporal control.
- Transcriptional regulatory elements and molecular machinery orchestrate gene expression patterns.
Purpose of the Study:
- To review classes of transcriptional regulatory elements.
- To discuss the molecular machinery involved in gene expression.
- To highlight the importance of transcriptional regulation in disease and genome annotation.
Main Methods:
- Review of scientific literature on transcriptional regulation.
- Discussion of molecular machinery interacting with regulatory elements.
- Overview of methods for identifying transcriptional regulatory elements.
Main Results:
- Identified various classes of transcriptional regulatory elements (promoters, enhancers, silencers, insulators, Locus Control Regions).
- Described the molecular machinery (transcription factors, activators, coactivators) interacting with regulatory elements.
- Provided examples of diseases linked to alterations in transcriptional components.
Conclusions:
- Accurate gene expression is vital for biological fidelity.
- Transcriptional regulatory elements and machinery are key to controlled gene expression.
- Methods for identifying regulatory elements are advancing genome annotation efforts.
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