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Antidiabetic agents from medicinal plants.

Mankil Jung1, Moonsoo Park, Hyun Chul Lee

  • 1Department of Chemistry, Yonsei University, Seoul 120-749, Korea. mjung@yonsei.ac.kr

Current Medicinal Chemistry
|May 25, 2006
PubMed
Summary

Natural products and medicinal plants show promise for treating type 2 diabetes. Research from 2001-2005 highlights specific compounds and herbs with significant antidiabetic activity, offering alternatives to conventional therapies.

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Area of Science:

  • Pharmacology
  • Ethnobotany
  • Natural Products Chemistry

Background:

  • Conventional treatments for non-insulin-dependent diabetes mellitus (type 2 diabetes) have limitations.
  • Natural products and herbal medicines are increasingly recognized for their therapeutic potential in diabetes management.
  • Traditional medicine systems have long utilized plants for treating diabetes.

Purpose of the Study:

  • To review medicinal plants and natural products with demonstrated antidiabetic activity.
  • To cover active natural components and crude extracts reported between 2001 and 2005.
  • To identify potential therapeutic agents for type 2 diabetes from natural sources.

Main Methods:

  • Literature review of scientific publications from 2001-2005.

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  • Identification of medicinal plants with experimental or clinical antidiabetic effects.
  • Analysis of isolated natural products (terpenoids, alkaloids, flavonoids, phenolics) and their reported activities.

    • Main Results:

    • Numerous natural products, including schulzeines A-C, radicamines A-B, and corosolic acid (Glucosol), exhibit significant antidiabetic potential.
    • Specific compounds like 2,5-imino-1,2,5-trideoxy-L-glucitol and beta-homofuconojirimycin show notable activity.
    • Medicinal herbs such as Momordica charantia, Pterocarpus marsupium, and Trigonella foenum graecum are identified as beneficial for type 2 diabetes.

    Conclusions:

    • A variety of natural products and medicinal plants possess significant antidiabetic properties.
    • These findings support the exploration of natural compounds as adjunct or alternative therapies for type 2 diabetes.
    • Further research into these natural agents could lead to novel diabetes treatments.