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Acute pancreatitis after anesthesia with propofol in a child with glycogen storage disease type IA

Sergio E Bustamante1, Elumalai Appachi

  • 1Department of Pediatric Critical Care, The Children's hospital at the Cleveland Clinic Foundation, Cleveland, OH 44195, USA.

Paediatric Anaesthesia
|May 25, 2006
PubMed

Insights

Glycogen storage disorder type 1A (GSD 1A) increases pancreatitis risk due to hypertriglyceridemia. A case study highlights acute pancreatitis post-propofol anesthesia in a child with GSD 1A.

Area of Science:

  • Biochemistry
  • Pediatrics
  • Anesthesiology

Background:

  • Glycogen storage disorder type 1A (GSD 1A) is an inherited metabolic disorder.
  • GSD 1A is associated with hypertriglyceridemia, increasing pancreatitis risk.
  • Drug-induced pancreatitis can occur via hypersensitivity, direct toxicity, or hypertriglyceridemia.

Observation:

  • A 4-year-old girl with GSD 1A underwent tonsillectomy and adenoidectomy.
  • Propofol was utilized for general anesthesia induction.
  • The patient developed acute pancreatitis postoperatively.

Findings:

  • This case presents a potential link between propofol anesthesia and acute pancreatitis in a pediatric patient with GSD 1A.
  • The mechanism may involve propofol-induced hypertriglyceridemia, exacerbating the underlying metabolic condition.

Implications:

  • Highlights the importance of considering anesthetic agents in patients with metabolic disorders.
  • Suggests vigilance for pancreatitis in GSD 1A patients receiving propofol.
  • Further research is needed to elucidate the specific risks and mechanisms.

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