Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cyclooxygenase 2: understanding the pathophysiological role through genetically altered mouse models.

Paloma Martín Sanz1, Sonsoles Hortelano, Lisardo Bosca

  • 1Centro de Investigaciones Biologicas CIB (CSIC), Centro Nacional de Investigaciones Cardiovasculares, Melchor Fernandez Almagro 3, 28029 Madrid, Spain.

Frontiers in Bioscience : a Journal and Virtual Library
|May 25, 2006
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

NOD1 is a key mediator of atrial myopathy in heart failure.

Theranostics·2026
Same author

Prevalence and incidence of chronic kidney disease in patients with primary biliary cholangitis.

Journal of gastroenterology·2026
Same author

Progression to cirrhosis in chronic hepatitis D with mild-to-moderate fibrosis: Insights from a multicenter European cohort.

JHEP reports : innovation in hepatology·2026
Same author

Design, semi-synthesis and biological evaluation of grandiflorenic acid derivatives as potent covalent NLRP3 inhibitors.

European journal of medicinal chemistry·2026
Same author

REACT Score, a Novel Scoring System, Improves the Prediction of Non-Elective Readmissions in Patients With Decompensated Cirrhosis.

Liver international : official journal of the International Association for the Study of the Liver·2026
Same author

Consensus document on the diagnosis, management, and treatment of chronic hepatitis B virus and hepatitis D virus infection in Spain.

Gastroenterologia y hepatologia·2026

Cyclooxygenase (COX)-2, an inducible enzyme, plays a role in inflammation and cell growth. Genetically modified mice models are crucial for understanding the physiological and pathological functions of COX-2.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Genetics

Background:

  • Cyclooxygenase (COX)-1 and -2 are key enzymes in prostanoid biosynthesis.
  • COX-1 is constitutively expressed for housekeeping functions.
  • COX-2 is inducible and linked to inflammation, cell growth, and carcinogenesis.

Purpose of the Study:

  • To elucidate the physiological and pathophysiological roles of COX-2.
  • To leverage advances in genetic engineering for studying enzyme function.

Main Methods:

  • Utilizing selective COX inhibitors to study enzyme characteristics.
  • Employing transgenic and gene-targeting approaches in mice.
  • Developing COX-2 genetically altered mouse models.

Main Results:

Related Experiment Videos

  • COX-2 selective inhibitors have aided in understanding enzyme functions.
  • Genetically modified mice provide valuable models for COX-2 research.

Conclusions:

  • Genetically altered mice are essential tools for dissecting the complex roles of COX-2.
  • Further research using these models will enhance understanding of prostanoid-related pathways.