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Repressed expression of the HER-2/c-erbB-2 proto-oncogene by the adenovirus E1a gene products
1Department of Tumor Biology, University of Texas, M.D. Anderson Cancer Center, Houston 77030.
Oncogene
|February 1, 1991
Abstract:
The E3 region of adenovirus induces down-regulation of epidermal growth factor receptor (EGFR) through endocytosis. Here we report that an EGFR-related protein, the HER-2/c-erbB-2 gene product, p185, is also down-regulated by adenovirus, but via a different mechanism. We found that the adenovirus E1a gene is responsible for the repression of HER-2/c-erbB-2 at the RNA level.