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Updated: Aug 8, 2026

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes
Published on: August 20, 2007
Emerging possibilities in the development and function of regulatory T cells
Kajsa Wing1, Zoltán Fehérvári, Shimon Sakaguchi
1Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Shogoin 53, Kawahara-cho, Sakyoku, Kyoto 606-8507, Japan. kajsa@frontier.kyoto-u.ac.jp
CD25+CD4+ Regulatory T cells (Treg) are crucial for immune suppression in areas like self-tolerance and transplantation. This review addresses current knowledge gaps in Treg development and function, highlighting ongoing research directions.
Area of Science:
- Immunology
- Cell Biology
Background:
- CD25+CD4+ Regulatory T cells (Treg) are vital for immune suppression.
- Their role is established in self-tolerance, transplantation, allergy, and immunity to tumors and microbes.
Purpose of the Study:
- To review the current understanding of Treg biology.
- To highlight controversies and future research directions in Treg development and suppression mechanisms.
Main Methods:
- Literature review of experimental data on Treg cells.
- Analysis of existing knowledge and identification of research gaps.
Main Results:
- Treg cells play a critical role in various clinical areas.
- Significant gaps persist in understanding Treg development and suppression mechanisms.
Conclusions:
- Further research is needed to fully elucidate Treg biology.
- Addressing current controversies will advance the field of immunology.
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