Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Compromised memory function in schizophrenia and temporal lobe epilepsy.

Hee J Yoo1, Sang A Lee, Seong Y Kim

  • 1Department of Psychiatry, University of Ulsan College of Medicine, Asan Medical Center, Songpa-gu, Seoul, Korea. junhkl@hanafos.com

The Journal of Neuropsychiatry and Clinical Neurosciences
|May 25, 2006
PubMed
Summary

Schizophrenia patients exhibit moderate verbal memory deficits, unlike epilepsy patients with specific verbal or visual impairments. This suggests a broader cognitive dysfunction in schizophrenia, not tied to a single lesion site.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Understanding the Second Year of the COVID-19 Pandemic From a Nursing Perspective: A Multi-Country Descriptive Study.

Journal of advanced nursing·2025
Same author

Barriers and facilitators on the HIV care continuum among adults living with HIV in high-income countries: a scoping review protocol.

Systematic reviews·2022
Same author

Contribution of the Sub-Surface to Electrocatalytic Activity in Atomically Precise La<sub>0.7</sub> Sr<sub>0.3</sub> MnO<sub>3</sub> Heterostructures.

Small (Weinheim an der Bergstrasse, Germany)·2021
Same author

LIN28A enhances regenerative capacity of human somatic tissue stem cells via metabolic and mitochondrial reprogramming.

Cell death and differentiation·2021
Same author

Prediction of Smoking Abstinence in Women Living With Human Immunodeficiency Virus Infection.

Nursing research·2020
Same author

Pilot Randomized Controlled Trial of a Digital Storytelling Intervention for Smoking Cessation in Women Living With HIV.

Annals of behavioral medicine : a publication of the Society of Behavioral Medicine·2019

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Psychiatry

Background:

  • Memory impairments are characteristic of schizophrenia and temporal lobe epilepsy (TLE).
  • TLE-related memory deficits offer a model for understanding lesion-specific memory dysfunction.
  • Schizophrenia's memory deficits are complex and may involve widespread neural network dysfunction.

Purpose of the Study:

  • To compare memory function in schizophrenia patients with that of left and right temporal lobe epilepsy (TLE) patients.
  • To investigate the nature of verbal and visual memory impairments in schizophrenia.
  • To determine if schizophrenia-related memory deficits are material-specific or indicative of generalized cognitive impairment.

Main Methods:

  • A comparative study involving healthy controls, schizophrenia patients, and TLE patients (left and right).

Related Experiment Videos

  • Assessment of immediate recall, delayed recall, and delayed retention across verbal and visual memory tasks.
  • Categorization of memory tasks into easy and difficult to analyze performance variations.

    • Main Results:

    • Left TLE patients showed severe verbal memory impairment; right TLE patients showed severe visual memory impairment.
    • Schizophrenia patients exhibited moderate impairment in immediate and delayed verbal memory.
    • Visual memory impairment in schizophrenia worsened with delayed recall, suggesting integrative dysfunction.

    Conclusions:

    • Schizophrenia is associated with moderate verbal memory deficits and amplified visual memory decline, indicating potential mesial temporal and frontal lobe integrative dysfunction.
    • Unlike TLE, schizophrenia's memory impairment may not stem from a single, selectively identifiable lesion site.
    • Utilizing memory tasks less susceptible to verbal mediation is crucial for accurately assessing memory dysfunction in schizophrenia.