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RADPLAT: an alternative to surgery?

Lee W T Alkureishi1, Remco de Bree, Gary L Ross

  • 1Department of Plastic Surgery, Christie Hospital, Southmoor Road, Manchester, United Kingdom, and Department of Otolaryngology/Head and Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands.

The Oncologist
|May 25, 2006
PubMed
Summary
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RADPLAT, a novel head and neck cancer treatment combining intra-arterial cisplatin with radiotherapy, shows promising results for unresectable cases. This approach may improve outcomes and preserve organ function in selected patients.

Area of Science:

  • Oncology
  • Radiotherapy
  • Pharmacology

Background:

  • Head and neck cancer often presents late, leading to poor prognoses.
  • Conventional treatments like surgery, radiotherapy, and chemotherapy have limitations, including severe toxicity with concurrent chemoradiation.
  • Advanced head and neck cancer requires innovative treatment strategies.

Purpose of the Study:

  • To review the evolution and application of the RADPLAT technique for treating head and neck cancer.
  • To evaluate the efficacy and safety of RADPLAT in patients with advanced head and neck cancer.
  • To explore the potential benefits of RADPLAT in both unresectable and resectable disease.

Main Methods:

  • RADPLAT involves intra-arterial delivery of cisplatin combined with systemic sodium thiosulphate neutralization and concurrent radiotherapy.

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  • This technique aims to achieve high cisplatin dose intensities while minimizing systemic toxicity.
  • The study reviews initial clinical trials and current applications of RADPLAT.

    • Main Results:

    • Excellent locoregional control rates have been observed in patients with unresectable head and neck cancer.
    • RADPLAT demonstrates a favorable side-effect profile compared to conventional chemoradiation.
    • Potential benefits include organ function preservation and improved quality of life in selected resectable cases.

    Conclusions:

    • RADPLAT is a promising treatment for advanced head and neck cancer, offering high efficacy with reduced toxicity.
    • Further phase III randomized controlled trials are necessary to compare RADPLAT directly with standard i.v. chemoradiation.
    • RADPLAT may represent a valuable therapeutic option for improving outcomes and quality of life in head and neck cancer patients.