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Melanostatin, a new melanin synthesis inhibitor. Production, isolation, chemical properties, structure and biological
Y Ishihara1, M Oka, M Tsunakawa
1Bristol-Myers Squibb Research Institute, Tokyo, Japan.
The Journal of Antibiotics
|January 1, 1991
Abstract:
Melanostatin, a new antibiotic with melanin synthesis inhibitor activity, was isolated from the fermentation broth of Streptomyces clavifer No. N924-2. Its structure was determined by spectral analysis and degradation experiments. Melanostatin strongly inhibited melanin formation in Streptomyces bikiniensis NRRL B-1049 and B16 melanoma cells.