Related Experiment Video
Updated: Aug 8, 2026
Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
Published on: January 12, 2022
Subretinal fibrosis and uveitis syndrome associated with ulcerative colitis
Graciana Fuentes-Páez1, Hernán Martínez-Osorio, José M Herreras
1Ocular Immunology and Uveitis Unit, Institute of Ophthalmobiology (IOBA), Facultad de Medicina, University of Valladolid, Calle Ramón y Cajal 7, Valladolid, 47005, Spain.
Background And Aims:
We report a case of subretinal fibrosis and panuveitis syndrome as an extraintestinal manifestation of ulcerative colitis.
Materials And Methods:
We present an interventional case report of a 40-year-old female patient with inactive ulcerative colitis referred to our center for refractory uveitis in her right eye.
Results/Findings:
She was diagnosed with subretinal fibrosis and uveitis syndrome after work-up ruled out tuberculosis, bartonellosis, Lyme disease, and sarcoidosis. Right eye multifocal choroiditis and panuveitis syndrome with subretinal fibrosis was diagnosed, and posterior pole subretinal fibrosis caused a 90% loss of visual efficiency. She had concurrent dermatological manifestations but no gastrointestinal symptoms. One year of immunosuppressive therapy with methotrexate (7.5 mg/week) controlled ocular inflammation. Two colitis episodes, with no visual involvement, were recorded during follow-up. Her final, right-eye, best-corrected visual acuity remained stable at 0.160 due to scarring sequela after 7 years of follow-up.
Interpretation/Conclusion:
Subretinal fibrosis and uveitis syndrome can occur as a sight-threatening extraintestinal manifestation of ulcerative colitis.
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