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Updated: Aug 8, 2026

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia
Published on: December 2, 2015
Impaired working speed and executive functions as frontal lobe dysfunctions in young first-degree relatives of
Silke Klemm1, Beate Schmidt, Susanne Knappe
1Dept. of Child and Adolescent Psychiatry, University of Jena, Philosophenweg 3-5, 07740 Jena, Germany. silke.Klemm@med.uni-jena.de
Abstract:
The aim of the investigation was to detect neuropsychological markers, such as sustained and selective attention and executive functions, which contribute to the vulnerability to schizophrenia especially in young persons. Performance was assessed in 32 siblings and children of schizophrenic patients and 32 matched controls using Wisconsin Card Sorting Test, Colour-Word-Interference-Test, Trail Making Test, and d2-Concentration-Test. The first-degree relatives showed certain impairments on all four tests, in particular, slower times on all time-limited tests. These results suggest the need for more time when completing neuropsychological tasks involving selected and focused attention, as well as cognitive flexibility, as a possible indicator of genetic vulnerability to schizophrenia.
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